How Might MDMA-Assisted Psychotherapy Work?
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In MDMA-assisted psychotherapy, MDMA is only administered a few times, and even a single session can have a profound effect. Conventional pharmaceutical treatments require patients to take drugs daily for months, years, or even their entire lives. 14
MDMA-assisted psychotherapy may show PTSD patients a way out. MDMA’s unique ability to reduce fear and increase interpersonal trust makes it well suited as an adjunct to psychotherapy for PTSD. 21
MDMA makes it easier for patients to be comfortable between the extremes of fear and avoidance. 19 Studies are exploring whether MDMA can increase the effectiveness of psychotherapy by strengthening the alliance between therapist and patient and opening a “window of tolerance” in patients. With MDMA-assisted psychotherapy, patients are able to experience and express fear, anger, and grief with less likelihood of feeling overwhelmed.
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It meant the world to me to be able to look at the fear, to look at the shame…When I got out of that session, I felt a hundred pounds lighter…The drug gave me the ability not to fear fear.
– Donna Kilgore, PTSD patient and MDMA-assisted psychotherapy study participant
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We estimate that it will take $2 million and three years to be ready for our End-of-Phase 2 meeting with the FDA, and an additional $10 million and seven years to complete Phase 3 and establish MDMA-assisted psychotherapy as a legally available treatment.
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