Existing treatments are not always effective. Two selective serotonin reuptake inhibitors (SSRIs)—paroxetine (Paxil®) and sertraline (Zoloft®)—are currently marketed as PTSD medications in the U.S. These drugs must be taken every day for a long period of time in order to be effective, increasing the prevalence of side effects.
A third of PTSD patients do not respond adequately to established psychotherapies. 2 15 Cognitive behavioral therapies such as prolonged exposure and cognitive processing therapy, psychodynamic therapy, eye movement desensitization and reprocessing, and other psychotherapeutic treatments for PTSD are all similarly ineffective for some patients. 16
Even after treatment, over a third of PTSD patients still have symptoms. 7